SOT 2015 Eminent Toxicologist Lecture Series - Reprogramming of the Human Genome by Toxic Injury

After an introduction to transposable elements, SOT Post President Kenneth Ramos, MD, PhD, PharmB, discusses his work on the LINE-1 (L1) retrotransposon. Toxic injury by chemicals such as benzo[a]pyrene reverses the silencing of L1 via epigenetic mechanisms, leading to disruption of the genome and potentially tumor formation.