2015 SOT Eminent Toxicologist Lecture Series—Reprogramming of the Human Genome by Toxic Injury

Lecturer: Kenneth Ramos, MD, PhD, PharmB, of the University of Arizona College of Medicine-Tucson.

After an introduction to transposable elements, SOT Post President Kenneth Ramos, MD, PhD, PharmB, discusses his work on the LINE-1 (L1) retrotransposon. Toxic injury by chemicals such as benzo[a]pyrene reverses the silencing of L1 via epigenetic mechanisms, leading to disruption of the genome and potentially tumor formation.