2016 Continuing Education Course: Human Health Risk Assessment: A Case Study Application of Principles (Part 1)

Chairperson(s): John C. Lipscomb, US Environmental Protection Agency, Cincinnati, OH; and Bette Meek, University of Ottawa, Ottawa, ON, Canada.

Endorser(s):
Regulatory and Safety Evaluation Specialty Section
Risk Assessment Specialty Section

This advanced, case study application course will build on course content previously presented and archived by the Society of Toxicology through CE courses presented in 2013 (Basic Principles of Human Risk Assessment) and 2014 (Methodologies in Human Health Risk Assessment). In this course, real world examples from publicly available, peer reviewed, completed risk assessments will be used as teaching aids. Course modules will be organized according to the four components of the Risk Assessment Paradigm: Hazard Characterization, Dose-Response Assessment, Exposure Assessment, and Risk Characterization. The Hazard
Characterization component will consist of a guided case study based evaluation of the strength and consistency of available hazard data culminating in a weight of evidence synthesis of hazard information; Dose-response information including default (allometric scaling), pharmacokinetic approaches including a live benchmark dose application from completed assessments will be presented and discussed; Information documenting actual (measured) exposure and/or data useful in determining a default measure of exposure will be presented and discussed; Risk Characterization will demonstrate the development of drinking
water maximum contaminant levels, maximum contaminant level-goals, reference values, and cancer slope factors; as well as methods to estimate risk at a given contaminant level. The course booklet will contain a worksheet on the risk assessment examples, to be completed during the
class. Unique to this course, students will be provided a risk assessment problem consisting of fundamental environmental contamination levels
and original publications describing toxicity studies and will be asked to characterize the hazard, estimate exposures via soil and water, develop
measures of toxic potency, and develop risk values for a hypothetical environmental contaminant. The results will be provided through an open access “drop box” type application.