Webinar Presented by the First Place Graduate Student and Postdoctoral Winners of the 2016 IVAM Specialty Section Awards
Date: Wednesday, May 18, 2016
Jenna Currier, PhD, US EPA
Title: What’s in a Tipping Point? Using Systems Biology to Characterize Adaptive and Adverse Oxidative Responses in Human Lung Cells
Abstract: Implementing high-throughput screening paradigms and risk assessment based on in vitro and in silico testing requires utilizing toxicity pathway information to distinguish adverse outcomes from recoverable adaptive events. However, little work has focused on oxidative stresses in human airway for the purposes of predicting adverse responses. This talk highlights research investigating molecular mechanisms at the tipping point of adaptive and adverse responses in human bronchial epithelial cells exposed to zinc, a model oxidant.
Advisor: Brian Chorley, PhD
Shih-Yu (Shirley) Chang, MS, PhC, University of Washington
Title: Proof of Concept Study—Microphysiological Systems (MPS) to Identify Organ-Organ Interactions in Toxicology: Hepatic Metabolism Enhances Nephrotoxicity of Aristolochic Acid
Abstract: MPS represent an interconnected set of cellular constructs designed to recapitulate the structure and function of human organs. MPS are also frequently referred to as organs-on-chips or in vitro organ constructs. Once validated, well-designed in vitro studies utilizing such systems could be transformative for future predictive toxicology studies. Although much work has been accomplished with individual organ-based MPS models, there has been relatively little achieved in utilizing combined organ MPS approaches to identify toxicologically relevant organ-organ interactions in vitro. This talk highlights some of the results from University of Washington’s collaborative research in liver-kidney-chip model to evaluate the toxicological impact of hepatic metabolism of Aristolochic Acid (AA), a well-known nephrotoxin and carcinogen, on its nephrotoxicity.
Advisor: David Eaton, PhD